Luminal agonists acting on P2Y receptors on the endothelial cell EC surface provide a flux of inositol trisphosphate IP3 into the endothelial cytosol. The model is able to relate a neuronal input signal to the corresponding vessel reaction contraction or dilation. The solution algorithm is shown to have excellent weak and strong scaling. Results have been generated for tissue slices containing up to blocks.
Government Printing Office Washington, D. If ever-increasing quantities of solid wastes are to be collected and disposed of, political entities must cooperate and seek solutions together. The solid waste management activities of one community do affect its neighbors.
Possible savings by a cooperative, regional approach to solid waste management are evident. For example, two small commu- nities may be able to operate one sanitary landfill less expensively than each operating alone.
Or, one large collection system can be more efficient than several smaller ones. If communities wish to cooperate in solving their solid waste management problems, the optimal use of their facilities and per- sonnel must be found.
Today's complicated solid waste systems suggest an approach that considers all interactions. A system may not be optimized by selecting the best components independently, because interactions between components are very significant. A systems analysis approach can provide a technique by which all com- ponents and their interactions are considered, and the total system optimized.
This study develops a systems analysis methodology for regional solid waste management. Although this initial effort is far from comprehensive, it can serve as a model for planners in the applica- tion of quantitative techniques for establishing more efficient solid waste systems.
I Introduction B-l B. I Introduction E-l E. I Summary G-l G. I Assumptions j-1 J. F Elapsed Time F. Elapsed Time F F. April 18,and April 1, A. April 3,and April 1, A. It has been demonstrated amply that associated with these activities are streams of waste which over the years have become alarmingly larger and more complex in nature.
With the growing severity of the solid waste problem, there has occurred, at least on the part of the Federal Government, a broader awareness of the need for drastic measures, both fiscal and technological, to alleviate the problem.
It is difficult to define what is meant by waste. Broadly stated, waste is a material that its producer does not want Ref. Although the product may have value to someone either in its present or in a converted stateif its producer does not ask for reimbursement for its removal it is considered to be waste, and at some stage, will enter a waste handling system, either private or public.
The point at which it is discarded is considered to be the beginning of a waste management system. There are operational problems in using this definition, however: Since the material may have either direct or indirect benefits to the community, region, or nation, a useful material may or may not be considered waste, depending on whether the producer's attitude coincides with the public's attitude.
The word "wastes" is a more accurate term than the singular, because the appropriate reference is usually to one or more wastes in any form - solid, liquid and gaseous - or any combination of them. However for simplicity, the singular form is used in reading for adjectives and adverbs Ref.
The classification of certain scrap materials as waste or not will fluctuate with the market for those scrap materials. Thus, changes in such conditions as material usage and availability, general economic factors, location of waste produced to potential users, etc. By assuming current waste producer attitudes and current practices with regard to fluctuating markets for scrap materials, an examination of waste management can be made without having to resolve conceptual difficulties arising from these limitations on the strict definition of "waste".
In a more general problem context than is appropriate for the current study, the definition of waste would be modified significantly by enlarging the spatial and temporal limitations, relaxing the economic constraints and introducing other variant factors e. It is evident that as the definition of waste is modified, the producers, amount and com- position of the commodity would change appreciably.
This study was directed toward development of some methodological first steps at systems analysis of regional solid waste management systems. The scope was regional, and it was sufficient to look toward short- to medium- range problems during these first stages.
For these reasons, and since the development of analytical techniques did not depend crucially on the inclusion or exclusion of specific materials from the waste category, the adoption of current techniques and practices is believed to be appropriate for the present study.
Rather,a brief summary of the current and foreseeable trends in the problems associated with solid waste would be helpful in providing a basis for appreciating the importance of deriving an effective solid waste management system.
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